Tumor-infiltrating T lymphocyte clonality predicts prognosis in human ovarian cancer
نویسندگان
چکیده
Background The prognostic significance of the number of tumorinfiltrating T cells has been demonstrated for many tumor types. In contrast, the significance of the tumorinfiltrating T cell clonality, which reflects the preferential infiltration or expansion of T cell clones in the tumor microenvironment, has not been clear because of the technical hurdles required for evaluating each T cell clone in the tumor. In order to delineate the complexity of T cell responses and define correlates of a protective immunity, we applied a recently developed deep T cell receptor (TCR)-sequencing technology (immunoSEQ) to paired frozen tumor tissues and peripheral blood mononuclear cells from 99 ovarian cancer patients.
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